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 | Acceso al texto completo restringido a Biblioteca INIA Las Brujas. Por información adicional contacte bibliolb@inia.org.uy. |
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Registro completo
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Biblioteca (s) : |
INIA La Estanzuela; INIA Las Brujas. |
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Fecha actual : |
20/05/2022 |
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Actualizado : |
30/11/2022 |
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Tipo de producción científica : |
Artículos en Revistas Indexadas Internacionales |
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Circulación / Nivel : |
Internacional - -- |
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Autor : |
BERTON, M. P.; DA SILVA, ROSIANE PEREIRA; BANCHERO, G.; MOURÃO, G. B.; FERRAZ, J. B. S.; SCHENKEL, F. S.; BALDI, F. |
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Afiliación : |
MARIANA PIATTO BERTON, Departamento de Zootecnia, Faculdade de Ciências Agrárias e Veterinárias, Universidade Estadual Paulista, Jaboticabal, Brazil; ROSIANE PEREIRA DA SILVA, Faculdade de Zootecnia e Engenharia de Alimentos, Universidade de São Paulo, Pirassununga, Brazil; GEORGGET ELIZABETH BANCHERO HUNZIKER, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; GERSON BARRETO MOURÃO, Departamento de Zootecnia, Escola Superior de Agricultura “Luiz de Queiroz”, Universidade de São Paulo/ESALQ, Piracicaba, Brazil; JOSE BENTO STERMAN FERRAZ, Faculdade de Zootecnia e Engenharia de Alimentos, Universidade de São Paulo, Pirassununga, Brazil; FLAVIO SCHRAMM SCHENKEL, Centre for Genetic Improvement of Livestock, University of Guelph, Guelph, ON, Canada; FERNANDO BALDI, Departamento de Zootecnia, Faculdade de Ciências Agrárias e Veterinárias, Universidade Estadual Paulista, Jaboticabal, Brazil. |
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Título : |
Genomic integration to identify molecular biomarkers associated with indicator traits of gastrointestinal nematode resistance in sheep. |
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Fecha de publicación : |
2022 |
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Fuente / Imprenta : |
Journal of Animal Breeding and Genetics, 2022, Volume 139, Issue 5, pages 502-516. doi: https://doi.org/10.1111/jbg.12682 |
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ISSN : |
0931-2668 |
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DOI : |
10.1111/jbg.12682 |
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Idioma : |
Inglés |
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Notas : |
Article history: Received 14 June 2021; Accepted 21 April 2022; First published 09 May 2022; Publisched online September 2022. -- Corresponding author: Berton, M.P.; Departamento de Zootecnia, Faculdade de Ciências Agrárias e Veterinárias, Universidade Estadual Paulista, Jaboticabal, Brazil; email:mapberton@gmail.com -- |
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Contenido : |
ABSTRACT.- This study aimed to integrate GWAS and structural variants to propose possible molecular biomarkers related to gastrointestinal nematode resistance traits in Santa Inês sheep. The phenotypic records FAMACHA, haematocrit, white blood cell count, red blood cell count, haemoglobin, platelets and egg counts per gram of faeces were collected from 700 naturally infected animals, belonging to four Brazilian flocks. A total of 576 animals were genotyped using the Ovine SNP12k BeadChip and were imputed using a reference population with Ovine SNP50 BeadChip. The GWAS approaches were based on SNPs, haplotypes, CNVs and ROH. The overlapping between the significant genomic regions detected from all approaches was investigated, and the results were integrated using a network analysis. Genes related to the immune system were found, such as ABCB1, IL6, WNT5A and IRF5. Genomic regions containing candidate genes and metabolic pathways involved in immune responses, inflammatory processes and immune cells affecting parasite resistance traits were identified. The genomic regions, biological processes and candidate genes uncovered could lead to biomarkers for selecting more resilient sheep and improving herd welfare and productivity. The results obtained are the start point to identify molecular biomarkers related to indicator traits of gastrointestinal nematode resistance in Santa Inês sheep. © 2022 Wiley-VCH GmbH. |
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Palabras claves : |
Copy number variant; GWAS; GWAS - Genome-wide association study; Haplotype; Integration analyses; Run of homozygosity; System biology. |
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Thesagro : |
OVEJA. |
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Asunto categoría : |
--
L10 Genética y mejoramiento animal |
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Marc : |
LEADER 02796naa a2200325 a 4500
001 1063154
005 2022-11-30
008 2022 bl uuuu u00u1 u #d
022 $a0931-2668
024 7 $a10.1111/jbg.12682$2DOI
100 1 $aBERTON, M. P.
245 $aGenomic integration to identify molecular biomarkers associated with indicator traits of gastrointestinal nematode resistance in sheep.$h[electronic resource]
260 $c2022
500 $aArticle history: Received 14 June 2021; Accepted 21 April 2022; First published 09 May 2022; Publisched online September 2022. -- Corresponding author: Berton, M.P.; Departamento de Zootecnia, Faculdade de Ciências Agrárias e Veterinárias, Universidade Estadual Paulista, Jaboticabal, Brazil; email:mapberton@gmail.com --
520 $aABSTRACT.- This study aimed to integrate GWAS and structural variants to propose possible molecular biomarkers related to gastrointestinal nematode resistance traits in Santa Inês sheep. The phenotypic records FAMACHA, haematocrit, white blood cell count, red blood cell count, haemoglobin, platelets and egg counts per gram of faeces were collected from 700 naturally infected animals, belonging to four Brazilian flocks. A total of 576 animals were genotyped using the Ovine SNP12k BeadChip and were imputed using a reference population with Ovine SNP50 BeadChip. The GWAS approaches were based on SNPs, haplotypes, CNVs and ROH. The overlapping between the significant genomic regions detected from all approaches was investigated, and the results were integrated using a network analysis. Genes related to the immune system were found, such as ABCB1, IL6, WNT5A and IRF5. Genomic regions containing candidate genes and metabolic pathways involved in immune responses, inflammatory processes and immune cells affecting parasite resistance traits were identified. The genomic regions, biological processes and candidate genes uncovered could lead to biomarkers for selecting more resilient sheep and improving herd welfare and productivity. The results obtained are the start point to identify molecular biomarkers related to indicator traits of gastrointestinal nematode resistance in Santa Inês sheep. © 2022 Wiley-VCH GmbH.
650 $aOVEJA
653 $aCopy number variant
653 $aGWAS
653 $aGWAS - Genome-wide association study
653 $aHaplotype
653 $aIntegration analyses
653 $aRun of homozygosity
653 $aSystem biology
700 1 $aDA SILVA, ROSIANE PEREIRA
700 1 $aBANCHERO, G.
700 1 $aMOURÃO, G. B.
700 1 $aFERRAZ, J. B. S.
700 1 $aSCHENKEL, F. S.
700 1 $aBALDI, F.
773 $tJournal of Animal Breeding and Genetics, 2022, Volume 139, Issue 5, pages 502-516. doi: https://doi.org/10.1111/jbg.12682
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